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19. Higgs GA, Flower RJ, Vane JR: A new approach to antiinflammatory drugs. Biochem Pharmacol 1979; 28: 1959-1961 Humes JL, Sadowski S, Galavage M, Goldenberg M, Subers E, Kuehl FA Jr, Bonney R: Pharmacological effects of non-steroidal antiinflammatory agents on prostaglandin and leukotriene synthesis in mouse peritoneal macrophages. Biochem Pharmacol 1983; 32: 2319-2322 Robok J, Duniec Z: The influence of some 3-amino2-pyrazoline derivatives on cyclooxygenase and lipoxygenase activities. Biochem Pharmacol 1983; 31: 1955-1959 Siegel MI, McConell RT, Bonser RW, Cuatrecasas P: The production of 5-HETE and leukotriene B in rat neutrophils from carrageenan pleural exudates. Prostaglandins 1981; 21: 123-132 Radmark O, Malmsten C, Samuelsson B: The inhibitory effects of BW 755C on arachidonic acid metabolism in human polymorphonuclear leukocytes. FEBS Lett 1980; 110: 213-215 Kirino T, Tamura AS, Sano K: A reversible type of injury following ischemia in the gerbil hippocampus. Stroke 1986; 17: 455-459 Dembinska-Kiec A, Simmet T, Peskar BA: Formation of leukotriene C4-like material by rat brain tissue. Eur J Pharmacol 1984; 99: 57-62 Piper PJ, Stanton AWB: Leukotrienes and the intracranial circulation, in Hayaishi O, Yamamoto S eds ; : Advances in Prostaglandin, Thromboxane, and Leukotriene Research, vol 15. New York, Raven Press, 1985, pp 333-337 27. Tagari P, Du Boulay GH, Aitken V, Boullin DJ: Leukotriene D4 and the cerebral vasculature in vitro and in vivo. Prostaglandins Leukotrienes Med 1985; ll: 281-297 28. Rosenblum WI: Constricting effect of leukotrienes on cerebral arterioles of mice. Stroke 1985; 16: 262-263 Palmer MR, Mathews WR, Hoffer BJ, Murphy RC: Electrophysiological response of cerebellar Purkinje neurons and leukotriene D4 and Bt Pharmacol Exp Ther 1981; 219: 91-96 Uzumaki H, Yamamoto S, Kako R: Effects of lipoxygenase and cyclooxygenase inhibitors on the induction of ornithine decarboxylase by and isoproterenol in mouse tissues. Carcinogenesis 1986; 7: 289-294 Minamisawa H, Terashi A, Katayama Y, Kanda Y, Shimizu J, Shiratori T, Inamura K, Kaseki H, Yoshino Y: Brain eicosanoid levels in spontaneously hypertensive rats after ischemia with reperfusion: Leukotriene C4 as a possible cause of cerebral edema. Stroke 1988; 19: 372-377 Yokota M, Tani E, Maeda Y, Kokubu K: Effect of 5lipoxygenase inhibitor on experimental delayed cerebral vasospasm. Stroke 1987; 18: 512-518 KEY WORDS hippocampus gerbils, for instance, discount zyban.

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