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Enter a stock symbol printable version novartis delivers strong performance in first half of 2007 h1 - report ; novartis delivers strong performance in first half of 2007 h1 - report ; basel, switzerland, july 17 marketwire - * group first-half net sales advance 14% + 11% in local currencies ; to usd 1 9 billion on solid contributions from all divisions * net income up 14% to usd 2 billion and eps rises 14% to usd 78 per share * operating income from continuing operations up 13% and net income from continuing operations advances 17% * new pharmaceutical brands - particularly tekturna, lucentis, exjade and exforge - performing dynamically; seven major regulatory approvals achieved to date in 2007 * proceeds from non-core divestments to fund targeted acquisitions and repurchase of up to approximately usd 4 billion of novartis shares by february 2008 * outlook maintained for record 2007 operating and net income for continuing operations; group net sales growth revised to mid-single-digits in local currencies * pharmaceuticals net sales growth expected to slow in second half of 2007, mainly from us generic competition for lotrel and lamisil and the zelnorm suspension key group figures first half + - + h1 2007 h1 2006 % change - + - + - + - % net net usd m sales usd m sales usd lc - + - + - net sales 19 941 17 - + - operating income 4 669 2 - net income 4 187 2 0 3 669 2 0 14 - basic earnings per usd usd share ads 78 56 14 second quarter + - + q2 2007 q2 2006 % change - + - + - + - % net net usd m sales usd m sales usd lc - + - + - net sales 10 122 9 - + - operating income 2 216 2 - net income 2 016 1 - basic earnings per usd usd share ads 86 73 18 basel, july 17, 2007 - commenting on the results, dr.
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De Morais MB; Vitolo MR; Aguirre AN; Medeiros EH; Antoneli EM; FagundesNeto U Departamento de Pediatrica da Universidade Federal de Sao-Paulo-Escola Paulista de Medicina UNIFESP-EPM ; . Arq Gastroenterol Brazil ; Apr-Jun 1996, 33 2 ; p93-101 The aim of this study was to evaluate the dietary fiber intake and the dietary habits of children with and without functional chronic constipation. We enrolled 58 children with functional chronic constipation and 58 controls without constipation matched for sex and age. Food and fiber intake were evaluated by 24 hour dietary recall and a complete clinical history was performed. The age of onset of constipation occurred during the first year of life in 55.4% of the patients while the median age of evaluation was 78 months. Soiling was found in 41.7% of patients. The median period of exclusive breast feeding was shorter P 0.002 ; in the constipation group one month ; than in the control group three month ; . The proportion of constipation was similar for mothers of children of both groups as well as for siblings in both groups. The fathers of children with constipation presented higher frequency of constipation 12.3% ; than the fathers of children in control group 1.8% ; , but the difference did not reach statistical significance P 0.06 ; . The amount of food measured by 24 hour recall was similar in both groups. The calorie intake of constipated children 1526 + - 585 calories day ; was lower P 0.07 ; than in the control group 1712 + - 513 calories day ; but the difference did not reach statistical significance. The intake of protein, fat and iron was lower in the constipation group than in the control group. The volume of cow's milk intake was similar in both groups. The median of total dietary fiber intake in the constipation group 13.5 g day ; was statistically P 0.009 ; lower than in the control group 16.8 g day ; . The daily intake of insoluble dietary fiber was also statistically lower P 0.001 ; in the constipation group 6.3 g ; than in the control group 9.4 g ; . The intake of soluble dietary fiber was similar in both groups. The intake of dietary fiber per 1, 000 calories of diet was 10.3 g in the constipation group and 10.4 in the control group P 0.41 ; . There was a considerable intersection of individual values in fiber intake of the constipation and control groups, suggesting that low fiber intake acts in association with others factors on the genesis of constipation in children. However, the low intake of insoluble fiber, 448.
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Adiponectin Adiponectin, the most abundantly secreted adipocytokine from differentiated adipocytes, has vasculoprotective, angiogenic, anti-inflammatory, and antiatherogenic properties Figure 3 ; .30, 31 High adiponectin levels are associated with a reduced risk of myocardial infarction in men, 23 while low serum adiponectin levels are reported in obese individuals and in those with hypertension, coronary artery disease, and type 2 diabetes.23, 31 In an in vitro study of human aortic endothelial cells, adiponectin reduced the attachment of monocytes to vascular endothelial cells, an early event in atherosclerotic vascular change.32 In ischemia-reperfusion injury and hypertrophic cardiomyopathy, adiponectin protects the myocardium against vascular damage through 2 important, independent mechanisms: stimulation of 5-adenosine monophosphate-activated protein kinase AMPK ; and activation of cyclo-oxygenase-2 COX-2 ; .30, 33 After cardiac damage, AMPK stimulation inhibits apoptosis in myocytes and fibroblasts and suppresses cardiac myocyte hypertrophy, that is, it inhibits hypertrophic remodeling.30 COX-2 activation mediates anti-inflammatory effects in cardiac cells.30 Future studies are expected to characterize more precisely the influence of adiponectin on apoptosis, inflammation, and hypertrophy in cases of established heart failure in which paradoxical low levels of adiponectin offer cardioprotection.30 The exact role of adiponectin in metabolism and inflammation is complicated by the variation in its 3 circulating forms: a hexamer, a trimer, and a low-molecularweight molecule.31 Adiponectin also has insulin-sensitizing effects. Hotta et al34 found that adiponectin levels are inversely related to fasting plasma insulin and glucose levels. Plasma concentrations of adiponectin were observed to be significantly lower in obese persons than in those of normal body weight.24 Additionally, weight loss in obese individuals leads to increased adiponectin levels, whereas.
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A. Palomki, L. Ylinen, S. Korhonen, P. Keskinen, S. Simell, J. Lumme, R. Veijola, P. Silen, P. Markula, T. Simell, A. Kupila, J. Ilonen, M. Knip, H. Hyty & O. Simell Juvenile Diabetes Research Foundation Center for Prevention of Type 1 Diabetes in Finland at Departments of Pediatrics, Universities of Turku, Oulu and Tampere, and Departments of Virology, Universities of Turku and Tampere, Finland Introduction: The aim of this study was to analyze the relationship between decreased first phase insulin response FPIR ; values in IVGGTs, appearance of autoantibodies and onset of T1D in children carrying HLA-conferred risk for T1D and participating in Type 1 Diabetes Prediction and Prevention Trial DIPP ; . All children included in this study had developed ICA alone or together with IAA, GADA or IA-2A before IVGTTs were performed. Methodology: 380 IVGTTs were performed to 145 index children followed from birth and 174 IVGTTs to 61 older at-risk siblings. In IVGTT the children received 0.5 g kg glucose ad 35 g ; 25% solution i.v. as a steady 3 min 15 s infusion. Samples were drawn from the catheter at -10, -4, 1, 3, 5, and 60 min. FPIR was calculated as the sum of serum insulin concentrations at 1 and 3 min. The 95% lower limit calculated from 60 healthy 1- to 5-year-old children was 38 mU L. Results: Mean FPIR values increased with increasing age in children who did not develop T1D during follow-up mean SD 3.3 2.0 years ; . In all age categories mean FPIR-values were lower in children who developed multiple autoantibodies compared to those who were constantly positive for only one autoantibody. A FPIR value under 38 mU L, for instance, lamisil cost.
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The diagnosis of diabetes carries considerable consequences and should therefore be made with confidence. If the patient has classical symptoms such as increased thirst and urine volume, unexplained weight loss, pruritus vulvae or balanitis ; or drowsiness or coma, associated with marked glycosuria, the diagnosis can be readily established by demonstrating fasting hyperglycaemia. If the fasting blood glucose concentration is in the diagnostic range shown in Table 1, an oral glucose tolerance test OGTT ; is not required. In such instances however, a confirmatory test should be performed as incomplete fasting may give rise to spurious diagnosis. The diagnosis can also be established if a random blood glucose estimation exceeds the diagnostic values indicated in Figure 1. An OGTT is performed if the diagnosis is uncertain and the blood glucose values are in the equivocal range. It is often sufficient to measure the blood glucose values only after fasting and 2 hours after a 75 g oral anhydrous ; glucose load. The diagnostic criteria are shown in Table 1. The requirements for diagnostic confirmation for a person presenting with severe symptoms and gross hyperglycaemia will differ from those of the asymptomatic patient whose blood glucose levels are just above the diagnostic cut-off values. For the asymptomatic patient, at least one additional test result with a value in the diabetic range is desirable. Clinical diagnosis should never be based on the presence of glycosuria alone. The diagnosis of diabetes in pregnancy follows the same criteria.
Stools. She never passed blood with these stools. She lost 11 kg weight in 3 y. She had temporary reduction in diarrhea and gain in weight while on anti-tubercular drug therapy given 3 mo after onset of this disease. She was emaciated body mass index 13.7 kg m2 ; , pale, had angular stomatitis and clubbed fingers. Investigations revealed: Hb 98 g normal 120150 ; , total leukocyte count 5.9 109 L normal 4.0 11.0 109 ; with normal differential counts, serum albumin 30 g L normal 4060 ; , serum iron 9.7 mol L normal 1129 serum bilirubin and transaminases were within normal limits. ELISA test for human immunodeficiency virus was negative. Sudan III stained spot-stool specimen showed 15 fat droplets high and monistat.
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The operating margin on ongoing activities was maintained in 1999 at 24.7% of sales, the same level as in 1998. Productivity gains were achieved in particular in administration and general overhead where expenses were reduced by 7% ; , and in manufacturing cost of goods sold growth was lower than sales growth ; . These gains were reinvested in marketing and distribution, which overall increased by 13%, and in research and development, which increased by 10%. Most of the marketing and distribution and research and development investments went into Pharmaceuticals, in order to support products like Neoral , Diovan and Lamjsil , as well as to prepare the launch of new products such as Exelon , Comtan , Trileptal and Starlix . This trend in the ongoing activities, with productivity gains in administration and general overhead and cost of goods sold, which are partially or totally reinvested in research and development, has continued over several years. Sales Year ended December 31 1999 1998 Change CHF m ; CHF m ; % ; Sales Pharmaceuticals Generics CIBA Vision Consumer Health excluding divested activities ; Animal Health Sales from ongoing activities Sales from discontinuing Agribusiness activities 1 ; Sales from divested Consumer Health activities Group sales and nabumetone and lamisil.
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